Graphitic-N-doped graphene quantum dots for photothermal eradication of multidrug-resistant bacteria in the second near-infrared window.
Bijiang GengYuan LiJinyan HuYuanyuan ChenJunyi HuangLongxiang ShenDengyu PanPing LiPublished in: Journal of materials chemistry. B (2022)
Developing efficient therapeutic strategies for combating bacterial infection remains a challenge owing to the indiscriminate utilization of antibiotics and the prevalence of multidrug-resistant (MDR) bacteria. Herein, highly graphitic-N-doped graphene quantum dots (N-GQDs) with efficient NIR-II photothermal conversion properties were synthesized for the first time for photothermal antibacterial therapy. The obtained N-GQDs exhibited strong NIR absorption ranging from 700 to 1200 nm, achieving high photothermal conversion efficiency of 77.8% and 50.4% at 808 and 1064 nm, respectively. Outstanding antibacterial and antibiofilm activities against MDR bacteria (methicillin-resistant Staphylococcus aureus , MRSA) were achieved by the N-GQDs in the presence of an 808 or 1064 nm laser. In vivo investigations verified that the generation of hyperthermia by N-GQDs plus a NIR-II laser can combat MDR bacterial infections and thus significantly accelerate wound healing. Our work provides a novel carbon-based nanomaterial as a photothermal antibacterial agent for efficiently avoiding bacterial resistance and fighting MDR bacterial infections.
Keyphrases
- photodynamic therapy
- multidrug resistant
- quantum dots
- methicillin resistant staphylococcus aureus
- drug release
- drug resistant
- gram negative
- acinetobacter baumannii
- fluorescence imaging
- wound healing
- klebsiella pneumoniae
- sensitive detection
- staphylococcus aureus
- cancer therapy
- silver nanoparticles
- drug delivery
- visible light
- anti inflammatory
- energy transfer
- stem cells
- escherichia coli
- risk factors
- essential oil
- highly efficient
- fluorescent probe
- high speed
- smoking cessation
- helicobacter pylori