Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective.
Abhilasha SoodArpit MehrotraUjjawal SharmaDiwakar AggarwalTejveer SinghMoyad ShahwanAmmar Abdulrahman JairounIsha RaniSeema RamniwasHardeep Singh TuliVikas YadavManoj KumarPublished in: Exploration of targeted anti-tumor therapy (2024)
In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant sources like honey, propolis, and certain fruits and vegetables. This active compound has garnered significant attention due to its promising therapeutic qualities and minimal toxicity. CH's ability to combat cancer arises from its multifaceted mechanisms of action, including the initiation of apoptosis and the inhibition of proliferation, angiogenesis, metastasis, and cell cycle progression. CH also displays potent antioxidant and anti-inflammatory properties, effectively counteracting the harmful molecules that contribute to DNA damage and the development of cancer. Furthermore, CH has exhibited the potential to sensitize cancer cells to traditional chemotherapy and radiotherapy, amplifying the effectiveness of these treatments while reducing their negative impact on healthy cells. Hence, in this current review, the composition, chemistry, mechanisms of action, safety concerns of CH, along with the feasibility of its nanoformulations. To conclude, the recent investigations into CH's anti-cancer effects present a compelling glimpse into the potential of this natural compound as a complementary therapeutic element in the array of anti-cancer approaches, providing a safer and more comprehensive method of combating this devastating ailment.
Keyphrases
- room temperature
- cell cycle
- anti inflammatory
- oxidative stress
- dna damage
- papillary thyroid
- cell cycle arrest
- human health
- induced apoptosis
- cell proliferation
- locally advanced
- squamous cell
- early stage
- endoplasmic reticulum stress
- cell death
- high resolution
- climate change
- risk assessment
- endothelial cells
- young adults
- radiation therapy
- vascular endothelial growth factor
- mass spectrometry
- lymph node metastasis
- pi k akt
- health risk
- rectal cancer