The rs1801280 SNP is associated with non-small cell lung carcinoma by exhibiting a highly deleterious effect on N-acetyltransferase 2.
Zahraa K LawiMohammed Baqur S Al-ShuhaibIbtissem Ben AmaraPublished in: Journal of cancer research and clinical oncology (2022)
Data indicated that rs1801280 SNP exerted a tight association with NSCLC since individuals with CC genotype exhibited the most damaging effects on the NAT2 that may be behind the low acetylation rates of this enzyme in patients with NSCLC.
Keyphrases
- small cell lung cancer
- genome wide
- advanced non small cell lung cancer
- high density
- single cell
- blood brain barrier
- cell therapy
- brain metastases
- electronic health record
- genetic diversity
- dna methylation
- stem cells
- gene expression
- epidermal growth factor receptor
- machine learning
- histone deacetylase
- mesenchymal stem cells