Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance.

Xinlin JiaoSiying ZhangJun JiaoTeng ZhangWenjie QuGuy Mutangala MuloyeBeihua KongQing ZhangBaoxia Cui

Published in: Clinical epigenetics (2019)

These findings give us the evidence that SEPT9 methylation could be a biomarker for cervical cancer diagnoses. It promotes tumorigenesis and radioresistance of cervical cancer by targeting HMGB1-RB axis and causes polarization of macrophages by mediating miR-375. We suggest SEPT9 could be a potential screening and therapeutic biomarker for cervical cancer.

Keyphrases

dna methylation
cell proliferation
transcription factor
genome wide
gene expression
dna damage response
oxidative stress
dna damage
cancer stem cells
risk assessment