Concordance of ASCL1, NEUROD1 and POU2F3 transcription factor-based subtype assignment in paired tumour samples from small cell lung carcinoma.

Thomas DenizeCatherine B MeadorAnna B RiderMaria L GanciJaimie L BarthMarina KemMari A Mino-Kenudson Yin Pun Hung

Published in: Histopathology (2023)

After accounting for technical factors, transcription factor-based subtyping was discordant among multiple SCLC samples in ~10% of patients, regardless of sample locations and time lapse. Our findings highlighted the spatiotemporal heterogeneity of SCLC in clinical samples and potential challenges, including technical and biological factors, that might limit concordance in SCLC transcription factor-based subtyping.

Keyphrases

transcription factor
end stage renal disease
dna binding
single cell
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
stem cells
climate change
bone marrow