Liver Organoids Generated from Mice with Necrotizing Enterocolitis Have Reduced Regenerative Capacity.

Hiromu MiyakeCarol LeeShogo SeoBo Li Agostino Pierro

Published in: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie (2019)

We report a novel technique to generate liver organoids during NEC. These organoids are characterized by reduced progenitor cells, reduced proliferation, and overall impaired regenerative capacity. Liver progenitor cells are important targets to prevent liver damage in NEC and promote recovery.

Keyphrases

stem cells
mesenchymal stem cells
cell therapy
type diabetes
skeletal muscle
preterm infants