Trajectories of Neurologic Recovery 12 Months After Hospitalization for COVID-19: A Prospective Longitudinal Study.
Jennifer A FronteraDixon YangChaitanya MedicherlaSamuel BaskharounKristie BaumanLena BellDhristie BhagatSteven BondiAlexander ChervinskyLevi DygertBenjamin FuchsDaniel GratchLisena HasanajJennifer HorngJoshua HuangRuben JaureguiYuan JiD Ethan KahnEthan KochJessica LinSusan LiuAnlys OliveraJonathan RosenthalThomas SnyderRebecca StainmanDaniel TalmasovBetsy ThomasEduard ValdesTing ZhouYingrong ZhuAriane LewisAaron S LordKara R MelmedSharon B MeropolSujata ThawaniAndrea B TroxelShadi YaghiLaura J BalcerThomas M WisniewskiSteven L GalettaPublished in: Neurology (2022)
At 12 months after hospitalization for severe COVID-19, 87% of patients had ongoing abnormalities in functional, cognitive, or Neuro-QoL metrics and abnormal cognition persisted in 50% of patients without a history of dementia/cognitive abnormality. Only fatigue severity differed significantly between patients with or without neurologic complications during index hospitalization. However, significant improvements in cognitive (t-MoCA) and anxiety (Neuro-QoL) scores occurred in 56% and 45% of patients, respectively, between 6 and 12 months. These results may not be generalizable to those with mild or moderate COVID-19.