Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants.

Eduardo D S FreitasKaton A KrasLori R RoustElena A De FilippisScot R KimballMatthew BurasChristos S Katsanos

Published in: Obesity (Silver Spring, Md.) (2023)

These findings indicate that lower protein synthesis observed in muscle of humans with obesity may result from diminished muscle IGF1 gene expression.

Keyphrases

skeletal muscle
gene expression
insulin resistance
metabolic syndrome
weight loss
type diabetes
binding protein
weight gain
high fat diet induced
dna methylation
squamous cell carcinoma
copy number
body mass index
locally advanced
radiation therapy
signaling pathway