Design and Pharmacophore Study of Triazole Analogues as Aromatase Inhibitors.

Published in: Anti-cancer agents in medicinal chemistry (2023)

The additional final SOMFA model created for the interactions between the enzyme & the letrozole blocker may be helpful for future modification and enhancement of the inhibitors of this crucial enzyme.

Keyphrases

molecular docking
molecular dynamics
adipose tissue
metabolic syndrome
skeletal muscle
molecular dynamics simulations
structure activity relationship