Serotonergic Regulation of Synaptic Dopamine Levels Mitigates L-DOPA-Induced Dyskinesia in a Mouse Model of Parkinson's Disease.

Yuan-Hao ChenTung-Tai KuoVicki WangPin-Wen ChengEagle Yi-Kung HuangKuo-Hsing MaNigel H GreigLars OlsonBarry J HofferKuan-Yin Tseng

Published in: Journal of Parkinson's disease (2024)

While both single injection of 5-HTP and Citalopram effectively mitigated the development of LID, the difference in mitigation of AIM subtypes may be linked to the unique effects of these two serotonergic agents on L-DOPA-derived DA and 5-HT metabolism.

Keyphrases

mouse model
high glucose
climate change
prefrontal cortex
diabetic rats
uric acid
drug induced
radiation induced
stress induced