Neoantigen Identification and Response to Adoptive Cell Transfer in Anti-PD-1 Naïve and Experienced Patients with Metastatic Melanoma.
Shoshana T LeviAmy R CopelandShirley K NahJessica S CrystalGabriel D IveyAlmin LalaniMohammad JafferjiBradley S WhiteNeilesh B ParikhVid LekoSri KrishnaFrank LoweryTodd D PrickettJared J GartnerLi JiaYong F LiAbraham SachsSivasish SindiriWelles RobinsonBillel GasmiJames C YangStephanie L GoffSteven A RosenbergPaul F RobbinsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
These results indicate that decreases in TMB and targeted neoantigens partially account for the difference in response to ACT and that additional factors likely influence responses in these patients. See related commentary by Blass and Ott, p. 2980.