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Effect of Pathway-specific Polygenic Risk Scores for Alzheimer's Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic Individuals.

Yuexuan XuEva VasiljevicYuetiva K DemingErin M JonaitisRebecca L KoscikCarol A Van HulleQiongshi LuMargherita CarboniGwendlyn KollmorgenNorbert WildCynthia M CarlssonSterling C JohnsonHenrik ZetterbergKaj BlennowCorinne D Engelman
Published in: medRxiv : the preprint server for health sciences (2023)
, the p-PRSs can predict age-dependent changes in beta-amyloid, tau, and cognition. Once validated, they could be used to identify individuals with an elevated genetic risk of accumulating beta-amyloid and tau, long before the onset of clinical symptoms.
Keyphrases
  • cerebrospinal fluid
  • cognitive decline
  • mild cognitive impairment
  • copy number
  • gene expression
  • sleep quality