Pharmacodynamic Impact of Carboxylesterase 1 Gene Variants in Patients with Congestive Heart Failure Treated with Angiotensin-Converting Enzyme Inhibitors.

Karl Emil Nelveg-KristensenPeter BieLaura FerreroDitte BjerreNiels E BruunMartin EgfjordHenrik B RasmussenPeter R Hansennull null

Published in: PloS one (2016)

These findings indicate that the included single variants of CES1 do not significantly influence plasma ATII/ATI ratios in CHF patients treated with ACEIs and are unlikely to be primary determinants of ACEI efficacy.

Keyphrases

angiotensin converting enzyme
copy number
heart failure
angiotensin ii
genome wide
left ventricular
dna methylation
genome wide identification
transcription factor
genome wide analysis