A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.

Runjie SongShuoqian MaJiajia XuXin RenPeilan GuoHuijiao LiuPeng LiFan YinMei LiuQiang WangLei YuJiali LiuBinwei DuanNafis A RahmanSławomir WołczyńskiGuangming LiXiangdong Li

Published in: Molecular cancer (2023)

These results reveal that a novel circZKSCAN1-encoded peptide acts as a tumor suppressor on PI3K/AKT/mTOR pathway, and sensitizes HCC cells to sorafenib via ubiquitination of mTOR. These findings demonstrated that circZKSaa has the potential to serve as a therapeutic target and biomarker for HCC treatment.

Keyphrases

induced apoptosis
signaling pathway
cell proliferation
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
genome wide
single cell
human health
risk assessment
combination therapy