A Short Synthesis of Aphanamol I in Both Racemic and Enantiopure Forms.
Steven J FerraraJonathan W BurtonPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclization, and a ring-expanding Claisen rearrangement.
Keyphrases