Consideration of within-patient diversity highlights transmission pathways and antimicrobial resistance gene variability in vancomycin-resistant Enterococcus faecium.
Martin P McHughKerry A PettigrewSurabhi TaoriThomas J EvansAlistair LeanordStephen H GillespieKate E TempletonMatthew T G HoldenPublished in: The Journal of antimicrobial chemotherapy (2024)
Patients can carry multiple sequence types of VREfm, and even within related lineages the presence of mobile genetic elements and antimicrobial resistance genes can vary. VREfm within-patient diversity could be considered in future to aid accurate resolution of transmission networks.
Keyphrases
- antimicrobial resistance
- genome wide
- end stage renal disease
- case report
- ejection fraction
- newly diagnosed
- copy number
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- genome wide identification
- escherichia coli
- gene expression
- patient reported outcomes
- methicillin resistant staphylococcus aureus
- current status
- genome wide analysis
- biofilm formation
- bioinformatics analysis
- candida albicans