Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.
Bryan G HarderSen PengChristopher P SeredukAndrej M SodomaGaspar J KitangeJoseph C LoftusJann N SarkariaNhan L TranPublished in: Molecular medicine (Cambridge, Mass.) (2019)
The understanding of how TMZ induces survival pathways, such as autophagy, may offer new therapeutic vulnerabilities and opportunities to use sequential inhibition of alternate pro-survival pathways that regulate autophagy. As such, identification of additional ways to inhibit TMZ-induced autophagy could enhance the efficacy of TMZ.