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Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.

Bryan G HarderSen PengChristopher P SeredukAndrej M SodomaGaspar J KitangeJoseph C LoftusJann N SarkariaNhan L Tran
Published in: Molecular medicine (Cambridge, Mass.) (2019)
The understanding of how TMZ induces survival pathways, such as autophagy, may offer new therapeutic vulnerabilities and opportunities to use sequential inhibition of alternate pro-survival pathways that regulate autophagy. As such, identification of additional ways to inhibit TMZ-induced autophagy could enhance the efficacy of TMZ.
Keyphrases
  • endoplasmic reticulum stress
  • cell death
  • induced apoptosis
  • cell cycle arrest
  • oxidative stress
  • signaling pathway
  • diabetic rats
  • high glucose
  • drug induced
  • pi k akt
  • endothelial cells
  • free survival
  • anti inflammatory