Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing.
Johanna K SandlingPascal PucholtLina Hultin RosenbergFabiana H G FariasSergey V KozyrevMaija-Leena ElorantaAndrei AlexssonMatteo BianchiLeonid PadyukovChristine BengtssonRoland JonssonRoald OmdalBenedicte A LieLaura MassarentiRudi SteffensenMarianne A JakobsenSøren T Lillevangnull nullKaroline LerangØyvind MolbergAnne VossAnne TroldborgSøren JacobsenAnn-Christine SyvänenAndreas JönsenIva GunnarssonElisabet SvenungssonSolbritt Rantapää-DahlqvistAnders A BengtssonChristopher SjöwallDag LeonardKerstin Lindblad-TohLars RönnblomPublished in: Annals of the rheumatic diseases (2020)
Our results show that pathway risk scores have the potential to stratify patients with SLE beyond clinical manifestations into molecular subsets, which may have implications for clinical follow-up and therapy selection.