Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease.

Sandhitsu R DasXueying LyuMichael Tran DuongLong XieLauren McCollumRobin de FloresMichael DiCalogeroDavid John IrwinBradford C DickersonIlya M NasrallahPaul A YushkevichDavid A Wolknull null

Published in: Annals of neurology (2021)

These data support the notion that a measure of deviation from a normative relationship between tau burden and neurodegeneration across brain regions in individuals on the AD continuum captures variability due to multiple underlying factors, and can reveal phenotypes, which if validated, may help identify possible contributors to neurodegeneration in addition to tau, which may ultimately be useful for cohort selection in clinical trials. ANN NEUROL 2021;90:751-762.

Keyphrases

cerebrospinal fluid
clinical trial
single cell
electronic health record
resting state
white matter
big data
multiple sclerosis
functional connectivity
risk factors
artificial intelligence
cerebral ischemia
machine learning
mild cognitive impairment