Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.
Vaibhav JainS RainaA P GhewareR SinghR RehmanV NegiTracy Murray StewartUlaganathan MabalirajanA K MishraR A CaseroAnurag AgrawalB GhoshPublished in: Allergy (2019)
Spermine induces BEC injury. Induction of polyamine catabolism may represent a novel therapeutic approach for asthma via reversing BEC stress.