Login / Signup

Automated glycan assembly of branched β-(1,3)-glucans to identify antibody epitopes.

M W WeishauptHeung Sik HahmA GeissnerPeter H Seeberger
Published in: Chemical communications (Cambridge, England) (2018)
β-(1,3)-Glucans exhibit immunomodulatory and anti-tumor effects. Since the isolation of pure β-(1,3)-glucan oligosaccharides from natural sources is complicated, especially when certain branching patterns are desired, chemical synthesis is frequently the only means of accessing these molecules. We report the iterative automated glycan assembly (AGA) of conjugation-ready linear and branched β-(1,3)-glucan oligosaccharides.
Keyphrases
  • deep learning
  • machine learning
  • high throughput
  • cell surface
  • drinking water
  • cell wall
  • computed tomography
  • magnetic resonance
  • single cell
  • dual energy