Proteomic Analysis of Human Scleroderma Fibroblasts Response to Transforming Growth Factor-ß.

Benjamin ChaigneGuilhem ClaryMorgane Le GallNicolas DumoitierClaire FernandezSebastien LofekPhilippe ChafeyPia MoinzadehThomas KriegChristopher P DentonLuc Mouthon

Published in: Proteomics. Clinical applications (2018)

That the proteome of fibroblasts differs between SSc patients and HC is confirmed, and it is demonstrated that fibroblasts exacerbate their proteomic phenotype upon stimulation with TGF-ß. EGFR and Pi3K are highlighted as proteins of interest in SSc fibroblasts.

Keyphrases

transforming growth factor
extracellular matrix
epithelial mesenchymal transition
small cell lung cancer
ejection fraction
newly diagnosed
endothelial cells
systemic sclerosis
epidermal growth factor receptor
patient reported outcomes
signaling pathway
label free