Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.

Ethan ShusterAmy E MilesLindsay K HeylandNavona CalarcoJerrold JeyachandraSalim MansourAristotle N VoineskosDavid C SteffensYuliya S NikolovaBreno S Diniz

Published in: International psychogeriatrics (2023)

We showed the LLD+Frailty group is associated with significant microstructural changes within WM tracts compared to Never-depressed+Robust individuals. Our findings indicate the possibility of a heightened neuroinflammatory burden as a potential mechanism underlying the co-occurrence of both conditions and the possibility of a depression-frailty phenotype in older adults.

Keyphrases

community dwelling
physical activity
depressive symptoms
sleep quality
risk factors
human health