Computational analysis of mRNA expression profiles identifies the ITG family and PIK3R3 as crucial genes for regulating triple negative breast cancer cell migration.
Sukhontip KlahanMei-Shin WuEdward HsiChi-Cheng HuangMing-Feng HouWei-Chiao ChangPublished in: BioMed research international (2014)
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (Her2/neu). TNBC has worse clinical outcomes than other breast cancer subtypes. However, the key molecules and mechanisms of TNBC migration remain unclear. In this study, we compared two normalized microarray datasets from GEO database between Asian (GSE33926) and non-Asian populations (GSE46581) to determine the molecules and common pathways in TNBC migration. We demonstrated that 16 genes in non-Asian samples and 9 genes in Asian samples are related to TNBC migration. In addition, our analytic results showed that 4 genes, PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton. Our results indicated potential genes that link to TNBC migration. This study may help identify novel therapeutic targets for drug development in cancer therapy.
Keyphrases
- genome wide
- estrogen receptor
- epidermal growth factor receptor
- bioinformatics analysis
- cell migration
- genome wide identification
- cancer therapy
- endothelial cells
- dna methylation
- drug delivery
- tyrosine kinase
- climate change
- young adults
- breast cancer cells
- induced pluripotent stem cells
- binding protein
- endoplasmic reticulum