Induced pluripotent stem cell-derived mesenchymal stem cells activate quiescent T cells and elevate regulatory T cell response via NF-κB in allergic rhinitis patients.

Xing-Liang FanQing-Xiang ZengXin LiCheng-Lin LiZhi-Bin XuXue-Quan DengJianbo ShiDong ChenSong Guo ZhengQing-Ling Fu

Published in: Stem cell research & therapy (2018)

iPSC-MSCs activate quiescent T cells and elevate regulatory T-cell response in AR patients, suggesting different immunomodulatory functions of iPSC-MSCs according to the phases of diseases. Therefore, iPSC-MSCs are a potential therapeutic candidate for treating allergic airway inflammation.

Keyphrases

stem cells
end stage renal disease
ejection fraction
mesenchymal stem cells
newly diagnosed
allergic rhinitis
chronic kidney disease
transcription factor
oxidative stress
immune response
bone marrow
cell proliferation
induced pluripotent stem cells
patient reported
diabetic rats
toll like receptor