Phenyliodonium diacetate mediated carbotrifluoromethylation of N-acylhydrazones.

A concise, efficient and direct trifluoromethylation method of aldehyde-derived N-acylhydrazones has been firstly developed by using the combination of inexpensive, stable and commercially available TMSCF3 and PhI(OAc)2 as the CF3 source under mild reaction conditions. This method provides easy access to highly functionalized trifluoromethylated N-acylhydrazones, which could be used as trifluoromethyl synthetic building blocks to be further transformed into other valuable trifluoromethyl compounds.