Paramagnetic rim lesions and the central vein sign: Characterizing multiple sclerosis imaging markers.
Margareta A ClarkeRachael CheekHabeeb F KazimuddinBryan HernandezReece ClarkeColin D McKnightJoy DerwenskusJames EatonRebecca IrlmeierFei YeKristin P O'GradyBaxter RogersSeth A SmithFrancesca BagnatoPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2023)
PRLs, but not CVS-positive lesions, are larger and have lower myelin integrity. Our findings indicate that PRLs are associated with higher levels of lesion-specific pathology prior to the start of disease-modifying therapy.