The µ-opioid system in midline thalamic nuclei modulates defence strategies towards a conditioned fear stimulus in male mice.
Xabier BengoetxeaLena GoedeckePeter BlaesseHans-Christian PapeKay JünglingPublished in: Journal of psychopharmacology (Oxford, England) (2020)
Fear extinction requires the integrity of the µ-opioid system in the dorsal midline thalamus. Pharmacological stimulation of MOR and associated facilitation of fear extinction recall suggest a potential therapeutic avenue for stress-related or anxiety disorders.