The µ-opioid system in midline thalamic nuclei modulates defence strategies towards a conditioned fear stimulus in male mice.

Xabier BengoetxeaLena GoedeckePeter BlaesseHans-Christian PapeKay Jüngling

Published in: Journal of psychopharmacology (Oxford, England) (2020)

Fear extinction requires the integrity of the µ-opioid system in the dorsal midline thalamus. Pharmacological stimulation of MOR and associated facilitation of fear extinction recall suggest a potential therapeutic avenue for stress-related or anxiety disorders.

Keyphrases

chronic pain
pain management
prefrontal cortex
deep brain stimulation
spinal cord
neuropathic pain
stress induced
drug induced