TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation.

Published in: PLoS biology (2021)

In this issue of PLOS Biology, Zhang and colleagues unveil a complex midgestational death during embryogenesis of mice harboring caspase-8 cleavage-resistant receptor-interacting protein (RIP) kinase (RIPK)1. Tumor necrosis factor (TNF) receptor (TNFR)1-dependent signaling drives cell death through a novel pathway requiring synergism between apoptotic and pyroptotic caspases.

Keyphrases

cell death
rheumatoid arthritis
oxidative stress
cell cycle arrest
protein kinase
dna binding
tyrosine kinase
induced apoptosis
transcription factor
high fat diet induced
signaling pathway