Monte Carlo simulations of randomized clinical trials in epilepsy.
Daniel M GoldenholzJoseph TharayilRobert MossEvan MyersWilliam H TheodorePublished in: Annals of clinical and translational neurology (2017)
This study suggests that RCT parameters can be improved over current practice to reduce costs while maintaining statistical power. In addition, use of a large-scale population dataset in a massively parallel computing analysis allows exploration of the wider parameter space of RCT design prior to running a trial, which could help accelerate drug discovery and approval.