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Monte Carlo simulations of randomized clinical trials in epilepsy.

Daniel M GoldenholzJoseph TharayilRobert MossEvan MyersWilliam H Theodore
Published in: Annals of clinical and translational neurology (2017)
This study suggests that RCT parameters can be improved over current practice to reduce costs while maintaining statistical power. In addition, use of a large-scale population dataset in a massively parallel computing analysis allows exploration of the wider parameter space of RCT design prior to running a trial, which could help accelerate drug discovery and approval.
Keyphrases
  • monte carlo
  • drug discovery
  • primary care
  • healthcare
  • clinical trial
  • study protocol
  • phase iii
  • phase ii
  • high intensity
  • molecular dynamics
  • quality improvement
  • open label
  • double blind
  • data analysis