Location of a single histidine within peptide carriers increases mRNA delivery.

Jiaxi HeSonghui XuQixin LengA James Mixson

Published in: The journal of gene medicine (2020)

H3K(+H)4b was a more effective carrier of mRNA than H3K4b. Mechanistic studies suggest that H3K(+H)4b polyplexes were more stable than H3K4b polyplexes. Lipopolyplexes formed with H3K(+H)4b markedly increased mRNA transfection.

Keyphrases

binding protein
case control