Brain mGlu5 Is Linked to Cognition and Cigarette Smoking but Does Not Differ From Control in Early Abstinence From Chronic Methamphetamine Use.

Megan N McClintickRobert M KesslerMark A MandelkernTarannom MahmoudieDaicia C AllenHilary LachoffJean-Baptiste F PochonDara G GhahremaniJudah B FarahiEdwin PartiaiRobert A CasillasLarissa J MooneyAndy C DeanEdythe D London

Published in: The international journal of neuropsychopharmacology (2024)

Abstinent MUD patients show no evidence of mGlu5 downregulation in brain, but association of VT in dorsolateral prefrontal cortex with verbal learning suggests that medications that target mGlu5 may improve cognitive performance.

Keyphrases

prefrontal cortex
white matter
end stage renal disease
working memory
resting state
chronic kidney disease
newly diagnosed
ejection fraction
peritoneal dialysis
prognostic factors
functional connectivity
signaling pathway
mild cognitive impairment