Decidual stromal cells promote the differentiation of CD56bright CD16- NK cells by secreting IL-24 in early pregnancy.
Hui-Li YangWen-Jie ZhouHan LuSha-Ting LeiSi-Yao HaZhen-Zhen LaiZi-Meng ZhengLu-Yu RuanYin-Yan HeDa-Jin LiMing-Qing LiJun ShaoPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
These data suggest that DSCs promote the differentiation of CD56bright CD16- NK with high levels of inhibitory receptors, immunotolerant, and angiogenic cytokines by secreting IL-24 during decidualization in early pregnancy.