The present study was intended to evaluate the effects of Paeonia emodi rhizome extracts on serum triglycerides (TGs), total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), atherogenic index (AI), superoxide dismutase (SOD), and glutathione peroxidase (GPx). The plant was extensively examined for its in vitro antioxidant activity, and the preliminary phytochemical screening was carried out using standard protocols. Male Wistar rats were induced with hyperlipidemia using high-fat diet and were treated orally with hydroalcoholic and aqueous extracts at the dose of 200 mg/kg bw for 30 days. TGs, TC, LDL-c, and AI were significantly reduced while HDL-c, SOD, and GPx levels rose to a considerable extent. After subjecting to acute toxicity testing, the extracts were found to be safe. The observations suggest antihyperlipidemic and antioxidant potential of P. emodi in high-fat diet induced hyperlipidemic/oxidative stressed rats.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- low density lipoprotein
- adipose tissue
- hydrogen peroxide
- oxidative stress
- artificial intelligence
- skeletal muscle
- metabolic syndrome
- drug induced
- amyotrophic lateral sclerosis
- anti inflammatory
- diabetic rats
- liver failure
- type diabetes
- human health
- high glucose
- ionic liquid
- hepatitis b virus
- nitric oxide
- machine learning
- risk assessment
- high density
- stress induced
- mechanical ventilation
- aortic dissection
- acute respiratory distress syndrome