CD8+ T-cell-Mediated Immunoediting Influences Genomic Evolution and Immune Evasion in Murine Gliomas.
Joshua R KaneJunfei ZhaoTakashi TsujiuchiBrice LaffleurVíctor A ArrietaAayushi MahajanGanesh RaoAngeliki MelaCrismita DmelloLi ChenDaniel Yang ZhangEdgar González-BuendiaCatalina Lee-ChangTing XiaoGerson RothschildUttiya BasuCraig HorbinskiMaciej S LesniakAmy B HeimbergerRaul RabadanPeter CanollAdam M SonabendPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our studies indicate that, in these tumor models, CD8+ T cells influence glioma oncogenic pathways, tumor genotype, and immunogenicity. This suggests immunoediting of immunogenic tumor clones through their negative selection by CD8+ T cells during glioma formation.