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Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice.

Koji SakurabaAkiko OyamadaKenjiro FujimuraRosanne SpolskiYukihide IwamotoWarren J LeonardYasunobu YoshikaiHisakata Yamada
Published in: Arthritis research & therapy (2016)
IL-21 signaling in B cells, but not in T cells, plays essential roles in the production of pathogenic autoantibodies that induce CIA development.
Keyphrases
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • diabetic rats
  • oxidative stress
  • type diabetes
  • metabolic syndrome
  • high fat diet induced
  • drug induced