Isavuconazole therapeutic drug monitoring in critically ill ICU patients: A monocentric retrospective analysis.

Rainer HöhlRalph Bertram Martina KinzigGolo-Sung HaarmeyerMatthias BaumgärtelArnim GeiseDorothea MuschnerDoris ProschMira RegerHans-Theodor Naumann Joachim H Ficker Jens C Kubitz Joerg SteinmannFritz Sörgel

Published in: Mycoses (2022)

This study shows that isavuconazole plasma concentrations vary in critical ill ICU patients. Significantly lower isavuconazole levels were associated with elevated BMI and higher SOFA score indicating a need of isavuconazole TDM in this specific patient population.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
intensive care unit
prognostic factors
patient reported outcomes
physical activity