Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways.

Pikun CaoBin LiuFeng DuDong LiYongzheng WangXiaoyan YanXiao LiYuliang Li

Published in: Thoracic cancer (2019)

SCU can suppress proliferation and promote apoptosis in A549 cells through AKT/mTOR/4EBP1 and STAT3 pathways. This suggests that SCU may be developed into a promising antitumor agent for treating NSCLC.

Keyphrases

cell cycle arrest
signaling pathway
induced apoptosis
cell proliferation
pi k akt
endoplasmic reticulum stress
cell death
oxidative stress
small cell lung cancer
advanced non small cell lung cancer