Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer.

Csilla OlahHenning ReisMichèle J HoffmannFabian MairingerSaskia TingBoris HadaschikUlrich KrafftViktor GrünwaldPeter NyiradyMelinda VaradiBalázs GyőrffyAndras KissEszter SzekelyGottfrid SjödahlTibor Szarvas

Published in: Cancer medicine (2022)

The proposed method robustly replicates the most commonly used transcriptome-based subtype classifications from paraffin-embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated APOBEC3G as a novel predictive marker for platinum-treated patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
gene expression
peritoneal dialysis
prognostic factors
single cell
rna seq
genome wide
bone marrow