Login / Signup

Predictive value of molecular subtypes and APOBEC3G for adjuvant chemotherapy in urothelial bladder cancer.

Csilla OlahHenning ReisMichèle J HoffmannFabian MairingerSaskia TingBoris HadaschikUlrich KrafftViktor GrünwaldPeter NyiradyMelinda VaradiBalázs GyőrffyAndras KissEszter SzekelyGottfrid SjödahlTibor Szarvas
Published in: Cancer medicine (2022)
The proposed method robustly replicates the most commonly used transcriptome-based subtype classifications from paraffin-embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated APOBEC3G as a novel predictive marker for platinum-treated patients.
Keyphrases
  • end stage renal disease
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • gene expression
  • peritoneal dialysis
  • prognostic factors
  • single cell
  • rna seq
  • genome wide
  • bone marrow