Effects of Locally Delivered Minocycline Microspheres in Postmenopausal Female Patients with Periodontitis: A Clinical and Microbiological Study.

The postmenopausal period, due to low hormonal concentrations, can exert a negative influence on both periodontitis and osteoporosis evolution. The present study aimed to identify potential clinical and microbiological benefic effects of locally delivered minocycline microspheres (Arestin ® ) in post-menopausal female patients with moderate and severe periodontitis. Probing depth, clinical attachment levels and bleeding on probing index, along with BANA tests for Porphyromonas gingivalis , Tannerella forsythia , and Treponema denticola , were performed before and at 3 months after a combined treatment of scaling, root planing (SRP), and Arestin ® placed in deep periodontal pockets. The association between SRP and Arestin ® exerted significant improvements in terms of clinical periodontal parameters, as well as significant reductions in the red complex bacteria detection.