Impact of the dead-time correction method on quantitative 177 Lu-SPECT (QSPECT) and dosimetry during radiopharmaceutical therapy.

While per-projection dead-time correction appears ideal for QSPECT, post-reconstruction correction is an acceptable alternative that is more practical to implement in the clinics, and that results in minimal deviations in quantitative accuracy and dosimetry estimates, as compared to the per-projection correction.