Unannotated small RNA clusters associated with circulating extracellular vesicles detect early stage liver cancer.
Johann von FeldenTeresa Garcia-LezanaNavneet DograEdgar Gonzalez-KozlovaMehmet Eren AhsenAmanda CraigStacey GiffordBenjamin WunschJoshua T SmithSungcheol KimJennifer E L DiazXintong ChenIsmail LabgaaPhilipp HaberReena OlsenDan HanPaula RestrepoDelia D'AvolaGabriela Hernandez-MezaKimaada AlletteRobert SebraBehnam SaberiParissa TabrizianAmon AsgharpourDouglas DieterichJosep M LlovetCarlos Cordon-CardoAsh TewariMyron SchwartzGustavo StolovitzkyBojan LosicAugusto VillanuevaPublished in: Gut (2021)
These findings directly lead to the prospect of a minimally invasive, blood-only, operator-independent clinical tool for HCC surveillance, thus highlighting the potential of unannotated smRCs for biomarker research in cancer.