Atherosclerosis Is a Smooth Muscle Cell-Driven Tumor-Like Disease.
Huize PanSebastian E HoChenyi XueJian CuiQuinian S JohansonNadja SachsLeila S RossFang LiRobert A SolomonE Sander ConnollyVirendra I PatelLars MaegdefesselHanrui ZhangMuredach P ReillyPublished in: Circulation (2024)
Our findings demonstrate that atherosclerosis is an SMC-driven tumor-like disease, advancing our understanding of its pathogenesis and opening prospects for innovative precision molecular strategies aimed at preventing and treating atherosclerotic cardiovascular disease.