Prevalence and determinants of resistance mutations in HIV-1-infected patients exposed to integrase inhibitors in a large Italian cohort.

Sara Modica Barbara RossettiF LombardiF LagiM MaffeoR D'AutiliaM PecorariI VicentiB BruzzoneG MagnaniS PaolucciD FrancisciG PencoD SacchiniM ZazziA De LucaAntonio Di Biagio

Published in: HIV medicine (2018)

The results support integrase resistance testing in INSTI-experienced patients. Emergence of INSTI resistance is facilitated by the reduced genetic barrier of the regimen as a consequence of resistance to companion drugs. However, INSTI resistance may become undetectable by standard population sequencing upon INSTI discontinuation.

Keyphrases

hiv infected patients
end stage renal disease
chronic kidney disease
ejection fraction
antiretroviral therapy
single cell
dna methylation
gene expression
genome wide
copy number