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Silent New Brain MRI Lesions in Children with MOG-Antibody Associated Disease.

Giulia FaddaBrenda BanwellPatrick J WatersRuth A MarrieE Ann YehJulia O'MahonyDouglas Lorne ArnoldAmit Bar-Ornull null
Published in: Annals of neurology (2020)
Anti-myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG) antibodies are associated clinically with either a monophasic or relapsing disease course. We investigated the frequency and clinical importance of acquired asymptomatic brain magnetic resonance imaging (MRI) lesions in a prospective incident cohort of 74 MOG-IgG positive children with serial MRI scans over a median of 5 years from presentation. Silent new lesions were detected in 14% of MOG-IgG positive participants, most commonly within the first months post-onset, with a positive predictive value for clinically relapsing disease of only 20%. Detection of asymptomatic lesions alone need not prompt initiation of chronic immunotherapy. ANN NEUROL 2021;89:408-413.
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