Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome.

Jung Beom Seo Yeon Kyung ChoiHye In WooYun A JungSungwoo LeeSeunghyeong LeeMihyang ParkIn Kyu LeeGwon Soo Jung Keun Gyu Park

Published in: Diabetes & metabolism journal (2019)

The present study shows that activation of the NLRP3 inflammasome contributes to UUO-induced renal fibrosis and the renoprotective effect of gemigliptin is associated with attenuation of NLRP3 inflammasome activation.

Keyphrases

nlrp inflammasome
high glucose
liver fibrosis
oxidative stress