Differential inflammasome activation predisposes to acute-on-chronic liver failure in human and experimental cirrhosis with and without previous decompensation.
Sofia MonteiroJosephine GrandtFrank Erhard UschnerNina KimerJan Lysgård MadsenRobert SchierwagenSabine KleinChristoph WelschLiliana SchäferChristian JansenJoan ClariaJosé Alcaraz-QuilesVicente ArroyoRichard MoreauJavier FernandezFlemming BendtsenGautam MehtaLise Lotte GluudSøren MøllerMichael PraktiknjoJonel TrebickaPublished in: Gut (2020)
Previous AD is an important risk factor for fatal ACLF development and possibly linked with inflammasome activation. Animal models confirmed the results showing a link between ACLF development and IL-1α in compensated cirrhosis and IL-1β in recompensated cirrhosis.