A novel AML1-ETO/FTO positive feedback loop promotes leukemogenesis and Ara-C resistance via stabilizing IGFBP2 in t(8;21) acute myeloid leukemia.

Wei ZhouSiying LiHong WangJingfeng ZhouShuyi LiGuofeng ChenWei GuanXianli FuClara NerviLi YuYonghui Li

Published in: Experimental hematology & oncology (2024)

Our work reveals a therapeutic potential of targeting AML1-ETO/FTO/IGFBP2 minicircuitry in the treatment for t(8;21) patients with resistance to Ara-C.

Keyphrases

cancer therapy
acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
transcription factor