Supramolecular Switching Surface for Antifouling and Bactericidal Activities.

Antibacterial materials are often bothered by the problems of drug-resistance-induction and adhesion-to-invalidation, coming from the exposure of reusable bactericidal materials before or after utilization. Herein, an efficient and easily transformable supramolecular switching surface for antifouling and bactericidal was successfully fabricated, through introducing a negatively charged macrocyclic host S6-corona[3]arene[3]pyridazine (S6-CAP) to a contact-killing surface constructed by a positively charged amphiphilic bactericide. The S6-CAP was able to fully switch off the bactericidal activity and make the surfaces antifouling. After switched on by simply washing off much of S6-CAP, the bactericidal activity was even better than the original contact-killing surfaces.