Temporal trends of severity and outcomes of critically ill patients with COVID-19 after the emergence of variants of concern: A comparison of two waves.
Daniela Helena Machado FreitasEduardo Leite Vieira CostaNatalia Alcantara ZimmermannLarissa Santos Oliveira GoisMirella Vittig Alves AnjosFelipe Gallego LimaPâmela Santos AndradeDaniel JoelsonsYeh-Li HoFlávia Cristina Silva SalesEster Cerdeira SabinoCarlos Roberto Ribeiro CarvalhoJuliana Carvalho FerreiraPublished in: PloS one (2024)
In this cohort study, patients with COVID-19 admitted to the ICU in the second wave were younger and had better prognostic scores. Adjusted survival was similar in the two waves, contrasting with record number of hospitalizations, daily deaths and health system collapse seen across the country in the second wave. Our findings suggest that the combination of the burden of severe cases and factors such as resource allocation and health disparities may have had an impact in the excess mortality found in many countries in the second wave.
Keyphrases
- public health
- healthcare
- intensive care unit
- risk factors
- mental health
- physical activity
- early onset
- copy number
- health information
- metabolic syndrome
- risk assessment
- skeletal muscle
- climate change
- insulin resistance
- human health
- extracorporeal membrane oxygenation
- affordable care act
- acute respiratory distress syndrome